Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.

ABSTRACT: The extracellular matrix (ECM) is a dynamic network structure that surrounds, supports, and influences cell behaviour. It facilitates cell communication and plays an important role in cell functions such as growth and migration. One way that cells interact with the ECM is via focal adhesions, which enable them to sense and respond to matrix mechanical properties and exert traction forces that deform it. This mechanical interplay between cells and the ECM, many aspects of which remain incompletely understood, involves the coordination of processes acting at different spatial scales and is highly influenced by the mechanical properties of the cells, ECM and focal adhesion components. To gain a better understanding of these mechanical interactions, we have developed a multiscale agent-based m

SUBMITTER: Arellano-Tinto J 

PROVIDER: S-EPMC12680367 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature