Real-world effectiveness of Avelumab maintenance in advanced urothelial carcinoma: results from the Italian multicenter MALVA study (Meet-URO 25).

ABSTRACT:

Importance

Avelumab maintenance therapy improves survival in patients with advanced urothelial carcinoma who respond to first-line platinum-based chemotherapy. However, real-world evidence on its effectiveness and on the prognostic value of baseline clinical factors remains limited.

Objective

To evaluate the real-world effectiveness of Avelumab maintenance therapy and to identify baseline prognostic factors associated with clinical outcomes.

Design

Multicenter prospective observational study including a retrospective cohort of patients treated before study initiation.

Setting

Several Italian oncology centers participating between 2021 and 2023.

Participants

A total of 251 patients with advanced or metastatic urothelial carcinoma who received Avelumab mai

SUBMITTER: Roviello G 

PROVIDER: S-EPMC12680435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature