Roux-en-Y Gastric Bypass Versus Single Anastomosis Duodeno-Ileal Bypass With Sleeve Gastrectomy: Different Mechanisms, Similar Outcomes.

ABSTRACT:

Objective

We aimed to compare the molecular mechanisms and metabolic outcomes of Roux-en-Y gastric bypass (RYGB) and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) using a preclinical model.

Methods

Otsuka Long-Evans Tokushima Fatty rats with diet-induced obesity underwent RYGB, SADI-S, or sham surgery. Metabolic parameters, including glucose tolerance, body weight, and 18F-fluorodeoxyglucose biodistribution, were assessed at 1- and 2-month postsurgery. The expression of Glucose transporter 1 (GLUT1) and glucose metabolism-related genes in intestinal segments was analyzed.

Results

Although RYGB and SADI-S yielded comparable improvements in glucose tolerance and body weight at 1 month postsurgery, they exerted their effects through distinct me

SUBMITTER: Shin HJ 

PROVIDER: S-EPMC12680477 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature