Polylactic- Glycolic Acid Microparticles-Encapsulated Prostaglandin E1 as A Novel Strategy In Triple Negative Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is characterized by unique clinical and pathological traits, from which its aggressive nature and the absence of specific treatments are the most worrying. Prostaglandin E₁ (PGE₁) can affect the morphology of human breast tumor cell lines, but its potential therapeutic effects appear to be counteracted by its high degradability in physiological environments. For this reason, polylactic-glycolic acid polymeric microparticles (MPs) are developed to stabilize PGE₁ in damp conditions and enable sustained local release for the treatment of TNBC after surgical removal of the tumor mass. Specifically, the PGE₁ embedded MPs are produced using a double emulsion solvent-evaporation method, then analyzed through Mastersi

SUBMITTER: Di Natale C 

PROVIDER: S-EPMC12680548 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature