One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies.

ABSTRACT: A new series of β-carboline-{α-acylaminoamide}-bisindole hybrids (12a-l) is designed and synthesized employing an atom-economical one-pot Ugi four-component reaction (U-4CR), affording the target compounds in good yields. All synthesized compounds (12a-l) are characterized by NMR, infrared, and mass spectrometry and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains. Notably, compounds 12b, 12g, and 12h display comparable minimum inhibitory concentrations values (302-303 µg mL^-1) against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, showing markedly improved activity relative to their parent compounds 6 and 9, which show weaker inhibition (MIC = 308-623 µg mL^-1). Molecular docking studies of compou

SUBMITTER: Atri AK 

PROVIDER: S-EPMC12680560 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature