ROS-Responsive Double-Layer Microneedles Enable Sequential Antibacterial and Immunomodulatory Therapy for Infected Wound Healing.

ABSTRACT: Background: The healing of chronically infected wounds is severely hindered by persistent inflammation, bacterial infection, and oxidative stress, posing great challenges to clinical therapy. To address these challenges, we designed a multifunctional dual-layer microneedles patch (MN@DOX+RES) featuring reactive oxygen species (ROS) responsiveness and dual drug delivery capabilities. This patch is engineered to deliver synergistic antibacterial, anti-inflammatory, and antioxidant effects, thereby promoting the healing of infected wounds. Methods: The dual-layer microneedles patch comprises a rapidly dissolvable HA backing layer loaded with DOX and a ROS-responsive tips layer composed of a crosslinked AHA-PBA/PVA matrix that encapsulates water-soluble RES inclusion complexes. A

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12680597 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature