Lymphocyte trajectories as prognostic indicators in intracerebral hemorrhage: a MIMIC-IV cohort study.

ABSTRACT: To examine the association between lymphocyte count trajectories and clinical outcomes in patients with spontaneous intracerebral hemorrhage (ICH) using data from the MIMIC-IV database. Patients with spontaneous ICH and at least two lymphocyte count measurements within the first 7 days of ICU admission were identified from the MIMIC-IV database. Latent growth mixture modeling was used to determine distinct lymphocyte trajectory groups. Kaplan-Meier survival curves and Cox proportional hazards models were employed to assess associations with mortality. Clinical characteristics and ICU length of stay were also compared between trajectory classes. A total of 841 patients were included. Two distinct lymphocyte trajectory classes were identified: Class 1 ("Increasing lymphocyte count") and Clas

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12680634 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature