Imaging and RNA sequencing-based radiogenomic analysis of occult lymph node metastasis and survival in lung adenocarcinoma staged non-metastatic.

ABSTRACT:

Background

We aimed to explore the value of a PET/CT-based radiomics signature in predicting occult lymph node metastasis (OLM) and outcomes in clinical N0 (cN0) lung adenocarcinoma (LUAD), to uncover the biologic meaning of OLM-associated radiomics phenotypes and to validate the reproducibility of the identified radiomics-correlated key genes.

Methods

A radiomics signature for OLM prediction was developed in a training cohort and validated across multiple validation and testing cohorts in this multicenter study. Prognostic implications of the radiomics score (Radscore) were assessed by measuring recurrence-free survival. Biologic processes and pathways were enriched and correlated with Radscore and each of the 8 radiomics phenotypes using paired PET/CT and RNA sequencing da

SUBMITTER: Ouyang ML 

PROVIDER: S-EPMC12680662 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature