Remote ischemic preconditioning improves ileal microvascular oxygenation during rodent hemorrhagic shock without improving variables of microcirculation and mitochondrial respiration.

ABSTRACT: Hemorrhagic shock is characterized by decreased microvascular blood flow, leading to a critical depletion of tissue oxygenation, particularly within the gastrointestinal tract. The integrity of the intestinal barrier, however, plays a crucial role in maintaining systemic homeostasis. Remote ischemic preconditioning (RIPC), achieved through transient, repeated occlusion of blood flow to a limb, has been shown to exert beneficial effects on various tissues under hypoxic conditions. These effects are at least in part attributed to circulating humoral mediators with vasoactive properties. This study aimed to investigate the effect of RIPC - implemented via intermittent bilateral hind limb perfusion occlusion - on intestinal microvascular oxygenation, regional microcirculation, and mitochondria

SUBMITTER: Hof S 

PROVIDER: S-EPMC12680664 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature