Failure of gamma knife radiosurgery for sporadic vestibular schwannomas: a systematic review and meta-analysis.

ABSTRACT:

Purpose

This review aims to characterize the limitations of Gamma Knife radiosurgery (GKRS) with investigation of failure rates for primary and salvage (post-surgical) cases, identification of risk factors associated with increased rates of treatment failure, and evaluation adverse outcomes.

Methods

A systematic search (Cochrane Library, PubMed, SCOPUS, and CINAHL) of studies on sporadic vestibular schwannomas treated with Gamma Knife radiosurgery was conducted in accordance with PRISMA guidelines. Primary outcome measures included continuous measures (mean), proportions (%), and relative risks (RR) with 95% confidence intervals (CI).

Results

Forty-three studies (n = 5619 patients) were included. The proportion of GKRS failure for primary (6.4% [95% CI 4.8-7.7]) and s

SUBMITTER: Taniguchi-Lo AN 

PROVIDER: S-EPMC12680672 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature