High-frequency ultrasound for microcirculation in metastatic mouse lymph node: contrast-free versus contrast-enhanced imaging.

ABSTRACT: Focal defects are one of the important features for the diagnosis of lymph node (LN) metastasis. In our previous study, an accurate method for detecting contrast agents was proposed. However, conventional B-mode and contrast-enhanced images via ultrasound contrast agents (UCAs) have the limitations of contrast and spatial resolution to visualize the microcirculation, such as focal defects to distinguish between benign and malignant LN. In the present study, we have developed a novel method based on clutter filtering with singular value decomposition (SVD) analysis using time-integrated amplitude envelope (TIAE) in high-frequency 40 MHz ultrasound for high contrast resolution of the microcirculation in LN tissue. A mouse LN was visualized in vivo without and with UCA to compare the contrast

SUBMITTER: Maeda K 

PROVIDER: S-EPMC12680702 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature