Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder. DNA repair dysfunction and integrated stress response (ISR) dysregulation have been implicated in PD pathophysiology, however, their role during the prodromal phase remains unclear. We analyzed longitudinal blood transcriptomic data from the Parkinson's Progression Markers Initiative to assess DNA repair and ISR genes in healthy individuals, prodromal PD, and those with established PD. Logistic regression classifiers showed that DNA repair and ISR expression distinguished prodromal PD from healthy individuals, with accuracy peaking in later prodromal stages. In contrast, these pathways did not separate established PD from controls, suggesting a more prominent role early in progression. Gene expression variability in prod

SUBMITTER: Anwer D 

PROVIDER: S-EPMC12680741 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature