Differential blood DNA methylation loci between Native Hawaiian and White women are associated with dietary patterns and metabolic biomarkers.

ABSTRACT: Epigenetic differences across racial/ethnic groups can provide insights into health disparities, including likely mechanisms and multifactorial upstream exposures at play. We compared the blood DNA methylome of Native Hawaiian (NatH) women, an understudied group with high chronic disease burden, with that of White women. Blood genome-wide DNA methylation profiling was performed in generally healthy, non-smoking NatH (n = 143) and White (n = 181) postmenopausal women in the Multiethnic Cohort. CpGs showing significant (Bonferroni p < 0.05) and substantial (delta-beta > 0.1) differential methylation in NatH compared to White women (CpGs-NatH) were identified through linear regression of methylation, adjusted for potential confounders. The CpGs-NatH were examined for gene pathways and for ass

SUBMITTER: Song MA 

PROVIDER: S-EPMC12680776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature