Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the ALBICS trial.

ABSTRACT:

Purpose

Fibrinogen is widely used in cardiac surgery. Still, reported associations between plasma fibrinogen level and chest tube drainage are weak. The results of trials on fibrinogen supplementation are contradictory. We aimed to investigate how the plasma fibrinogen level relates to severe bleeding and resternotomy for bleeding in patients undergoing on-pump cardiac surgery.

Methods

We conducted an observational post hoc study of 1,386 patients undergoing on-pump cardiac surgery enrolled in the Albumin in Cardiac Surgery (ALBICS) trial. We assessed severe bleeding with the Universal Definition of Perioperative Bleeding classification (UDPB), categorized as "UDPB-low" (classes 0-2) and "UDPB-high" (classes 3-4) and as resternotomy. We measured plasma fibrinogen levels preo

SUBMITTER: Talvasto A 

PROVIDER: S-EPMC12680795 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature