Brain-Derived Neurotrophic Factor and Heat Shock Protein-32: Potential Targets for Microglial Response to Glucose and Oxygen Manipulation.

ABSTRACT: Diabetes mellitus-induced mood disorders have physiologically demanding outcomes. Despite the severe outcomes of these comorbidities, the pathogenic mechanisms remain unclear. Hyperglycemia and hypoxia are key features of these conditions. Research indicates that brain-derived neurotrophic factor (BDNF), mainly secreted by microglial cells in response to neuronal stress, plays a role. Encephalic heat shock proteins (HSPs) may protect neurons by preventing death and promoting survival. Therefore, this study investigates (i) the effects of increased glucose concentrations (IGCs) on BDNF expression, (ii) the effects of hypoxia on BDNF expression, (iii) the combined effects of IGCs and hypoxia on BDNF expression, and (iv) the expression of HSPs-27, -32, and -70 under various conditions of IGCs

SUBMITTER: Mussa BM 

PROVIDER: S-EPMC12680829 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature