Blood transfusion and acute kidney injury after cardiac surgery: a retrospective observational study.

ABSTRACT:

Purpose

Cardiac surgery-associated acute kidney injury (AKI) is linked to poor outcomes. An observational study from Copenhagen, Denmark identified perioperative red blood cell (RBC) transfusion as a modifiable risk factor for AKI, with a dose-dependent relationship between the number of RBC units transfused and the occurrence and severity of AKI. We aimed to externally validate those findings in a larger population.

Methods

We conducted a retrospective observational study of adult patients undergoing nonemergent on-pump cardiac surgery at Toronto General Hospital (Toronto, ON, Canada) between 2016 and 2021. Acute kidney injury was classified using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Data were analyzed using inverse probability weighted logistic r

SUBMITTER: Boyko Y 

PROVIDER: S-EPMC12680830 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature