Efficacy and safety of natural killer cell therapy for the treatment of advanced non-small cell lung cancer: A meta-analysis and systematic review.

ABSTRACT: To evaluate the efficacy and safety of natural killer (NK) cell therapy for the treatment of advanced non-small cell lung cancer (NSCLC). Relevant studies on NK cell therapy for advanced NSCLC were collected from PubMed, Scopus, Embase and the Cochrane Library up to August, 2024. Two reviewers independently screened the articles and retrieved the data using the Cochrane risk assessment tool. Meta-analysis was conducted with R (version 4.3.1). A total of nine trials were analyzed, including five phase 2 randomized controlled and four phase 1 studies. All were medium to high quality but exhibited high performance and attrition biases. NK cell treatment doses ranged from 1×10⁹ to 4×10⁹ cells for 2 or 3 cycles. In total, 324 patients with advanced NSCLC were included, com

SUBMITTER: Li Z 

PROVIDER: S-EPMC12680858 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature