Fibroblast-derived NEU1 as a therapeutic target for improving cortical bone integrity and fracture healing.

ABSTRACT: Rationale: Bone fractures, particularly in aging populations, present significant clinical challenges due to prolonged healing times and increased risk of complications. A deeper understanding of the molecular mechanisms regulating bone metabolism and repair is essential for developing novel therapeutic strategies. Methods: Through performing immunohistochemical staining and observation on the hind limbs of mice, we evaluated the differences in the spatial distribution of osteoclasts and sialic acid-enriched regions, and further investigated the correlation between osteoclast activation and sialic acid levels in the bone microenvironment. Additionally, single-cell sequencing was conducted to infer the main cell subsets involved in the modification of sialic acid levels in the

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12680898 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature