Considerations for Patient Privacy of Large Language Models in Health Care: Scoping Review.

ABSTRACT:

Background

The application of large language models (LLMs) in health care holds significant potential for enhancing patient care and advancing medical research. However, the protection of patient privacy remains a critical issue, especially when handling patient health information (PHI).

Objective

This scoping review aims to evaluate the adequacy of current approaches and identify areas in need of improvement to ensure robust patient privacy protection in the existing studies about PHI-LLMs within the health care domain.

Methods

A search of the literature published from January 1, 2022, to July 20, 2025, was performed on July 20, 2025, using 2 databases (PubMed and Embase). This scoping review focused on the following three research questions: (1) What studies on the

SUBMITTER: Zhong X 

PROVIDER: S-EPMC12680930 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature