Encapsulated Indigenous Lactic Acid Bacteria Strains From Traditional Iranian Cheese Alleviate Hyperglycemia and Inflammation in Streptozotocin-Induced Diabetic Rats.

ABSTRACT: The current study was conducted to investigate the antidiabetic and anti-inflammatory effectiveness of encapsulated indigenous lactic acid bacteria originating from traditional Iranian cheese. Two out of 40 gram-positive, catalase-negative strains were selected and identified as Lactiplantibacillus pentosus and Lactiplantibacillus plantarum. Both strains exhibited strong acid (pH 2.5) and bile (0.3%) tolerance, with survival rates exceeding 64%. In vitro hydrophobicity (> 63%), autoaggregation (> 66%), and coaggregation with Escherichia coli (over 51%) were observed. These strains also demonstrated the highest antimicrobial activity (inhibition zones up to 27 mm) and were selected for in vivo testing. Male Wistar rats (n = 32) were randomly assigned to four grou

SUBMITTER: Nami Y 

PROVIDER: S-EPMC12681064 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature