Aortic root replacement versus preservation in acute type A aortic dissection repair: meta-analysis of reconstructed time-to-event data.

ABSTRACT:

Background

Outcomes of aortic root replacement (ARR) versus conservative root approach (CRA) in patients undergoing acute type A aortic dissection (ATAAD) repair remained controversy.

Methods

The present study was a pooled meta-analysis of Kaplan-Meier-derived individual patient data (IPD) from comparative studies published by September 29, 2024.

Results

Forty studies met our eligibility criteria, comprising 11,734 patients (4212 in the ARR group and 7522 in the CRA group). In the overall population, the overall survival was similar between the ARR and CRA groups (hazard ratio [HR], 0.95; 95% CI, 0.87-1.02; p = 0.17, log-rank test p = 0.47), while ARR was associated with lower risk of reoperation compared with CRA (HR 0.72; 95% CI, 0.59-0.87; p < 0.001, log-rank test

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12681094 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature