Ambient PM_2.5 and O₃ and their combined effects on the onset of acute cardiovascular events: a time-stratified case-crossover study in Jining, China (2015-2023).

ABSTRACT:

Background

The existing literature on the associations between short-term exposure to PM_2.5 and O₃ and acute cardiovascular events (ACE) has yielded inconclusive findings, and little is known about the potential interactions of PM_2.5 and O₃. This study aims to analyze the impacts of PM_2.5 and O₃ on ACE onset and their potential interactions.

Methods

A time-stratified case-crossover study was implemented to examine 424,069 cases of ACE in Jining City, China, between 2015 and 2023. This study used each case as its own control. PM_2.5 and O₃ concentrations were allocated to each case and control day based on the home address of each individual. Quantitative effects of short-term exposure to P

SUBMITTER: Song SH 

PROVIDER: S-EPMC12681133 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature