Associations of high protein supplements with gut microbiota and skeletal muscle mass in hospitalized older people.

ABSTRACT:

Background/objective

Prolonged bed rest is highly prevalent among hospitalized older adults and markedly accelerates the loss of muscle mass and physical function. Currently, there are no effective interventions to counteract this decline, and the underlying mechanisms remain poorly characterized. This study aimed to investigate whether high protein intake can simultaneously modulate muscle mass and the gut microbiota, and whether gut microbial composition mediates muscle regulation in hospitalized older people.

Methods

A self-controlled study was conducted on 43 older patients aged 60 to 90 years old with low skeletal muscle mass. During the 3-month intervention phase, all participants received approximately 36 g of high-protein supplementation daily, comprising both casein

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12681135 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature