Effects of combined nutritional supplementation and exercise on proxy measures of muscle mass, strength, and function in older adults with sarcopenia: a 12-week multicentre RCT.

ABSTRACT:

Background

Although nutritional supplementation and exercise have shown independent efficacy in managing sarcopenia, data supporting their combined implementation in real-world clinical settings remain limited.

Methods

This 12-week multicenter randomized controlled trial enrolled 110 older adults (≥ 65 years) with sarcopenia or possible sarcopenia. Participants were randomly allocated (1:1) to either the intervention group (n = 55) or control group (n = 55). In addition to their habitual diets, the intervention group received daily muscle-targeted oral nutritional supplementation (MT-ONS, 2 × 10 g sachets/day: containing 8.4 g protein, 0.5 g calcium β-hydroxy-β-methylbutyrate, 200 IU D3 per sachet) alongside a structured exercise programs featuring twice-weekly resistance tr

SUBMITTER: Sun J 

PROVIDER: S-EPMC12681163 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature