Automatic determination of glymphatic flow with the DTI-ALPS-index along the principal axis system in native imaging space corrects for head and fiber orientation.

ABSTRACT:

Purpose

The aim of this work is to make the DTI along the perivascular space (DTI-ALPS-index) more robust with respect to region selection and the orientation of the head and fibers. We propose to address this matter by using the principal diffusion directions and an automated, atlas-based region of interest (ROI) placement.

Methods

Simulations were used to determine the dependence of the DTI-ALPS-index on the orientations of the head and nerve fibers. Human MRI was performed on 12 healthy volunteers at 3T using a 64 channel head coil (Cima.X Siemens), and the DTI-ALPS-index was calculated along the principal diffusion directions (ALPS-PAS) and along the field of view or laboratory frame (ALPS-LAB). To calculate the DTI-ALPS-index with reduced bias in native space, we develo

SUBMITTER: Ajouz A 

PROVIDER: S-EPMC12681304 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature