Optimization of pseudo-continuous arterial spin labeling for brain perfusion imaging in the intraoperative setting.

ABSTRACT:

Purpose

Pseudo-continuous arterial spin labeling (PCASL) efficiency during intraoperative MRI is degraded due to large field inhomogeneities observed in some patients and lower arterial blood velocities induced by anesthesia. The purpose of this work was to maximize labeling efficiency during intraoperative MRI by optimizing PCASL parameters at 3 T.

Methods

Effects of PCASL labeling pulse interval and gradient parameters on labeling efficiency were first investigated by numerical simulations based on Bloch equations. PCASL parameters were modified accordingly, considering hardware constraints, and evaluated experimentally. An experiment in healthy volunteers compared three labeling pulse intervals. In intraoperative brain tumor patients, different configurations were tested

SUBMITTER: Sanchez-Albardiaz C 

PROVIDER: S-EPMC12681307 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature