On the structural and practical identifiability of multi-echo BBB-ASL tracer kinetic models.

ABSTRACT:

Purpose

Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it will likely impact parameter uncertainty. Here, we analyze the identifiability of two-compartment models used in multi-echo (ME) blood-brain-barrier (BBB)-ASL and evaluate the reliability of the fitted water-transfer rate (kw$$ \Big({k}_w $$ ).

Method

The identifiability of two variants of a two-compartment model (referred to here as "series" and "parallel") were analyzed using sensitivity matrix and Monte-Carlo simulation methods, the latter including the effects of noise and fixed-parameter error. ME-ASL data were collected at 3T in 25 co

SUBMITTER: Manson TJ 

PROVIDER: S-EPMC12681319 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature