Association Between Subclinical Hypothyroidism and MASLD: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder that can progress to cirrhosis and hepatocellular carcinoma. Although overt hypothyroidism has been identified as a MASLD risk factor, the impact of subclinical hypothyroidism (SCH), which affects approximately 4.6% of US adults, remains unclear. We conducted a systematic review and meta-analysis to determine whether SCH is independently associated with MASLD and to inform targeted screening recommendations.

Methods

We systematically searched PubMed, Embase, Cochrane, ClinicalTrials.gov, and Web of Science up to June 2025 for studies evaluating the association between SCH and MASLD. Random-effects meta-analyses were performed on eligible cross-sectional an

SUBMITTER: Amdetsion GY 

PROVIDER: S-EPMC12681400 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature