Mental health status and cardiovascular outcomes across Life's Essential 8 categories.

ABSTRACT:

Background

Anxiety and depression are established risk factors for cardiovascular disease (CVD); impacts of these conditions on cardiovascular outcomes across different levels of cardiovascular health (CVH), measured by Life's Essential 8 (LE8) scores, remain unclear.

Methods and results

We analyzed 290,778 UK Biobank participants (mean age 56.5, 56.1 % male) without prior CVD. CVH was assessed using the LE8 score. Mental health status (healthy, anxiety only, depression only, or comorbid anxiety and depression) was determined through PHQ-4 items and ICD-10 codes (F32-F33 for depression, F40-F41 for anxiety). Cardiovascular outcomes were defined as a composite of coronary heart disease (CHD), heart failure (HF), and stroke. Cox proportional hazards models were adjusted for co

SUBMITTER: Li E 

PROVIDER: S-EPMC12681446 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature