The role of the gut microbiome in the progression of Parkinson's disease: a systematic review of patient cohorts.

ABSTRACT:

Introduction

Parkinson's disease (PD) is the second most common neurodegenerative disease. The etiology of PD is not yet fully understood. In recent years, the role of the gut microbiome in the progression of the disease came to attention. A deeper understanding of the relationship between the gut microbiome and the development and progression of PD may innovate therapeutic approaches.

Aim

The aim of the present literature analysis is to systematically evaluate alterations in gut microbiome in PD and its correlation with clinical symptoms.

Materials and methods

A search for publications via PubMed using the search terms "Parkinson's disease" AND "gut microbiome" AND "human" was performed. The main inclusion criteria were a subject number ≥ 30 per group, patients with

SUBMITTER: Peters M 

PROVIDER: S-EPMC12681464 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature