5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6.

ABSTRACT:

Background

Hypobaric hypoxia (HH)-induced acute lung injury (ALI) is a growing concern. Tryptophan metabolite 5-Methoxytryptophan (5-MTP) is a recently identified endothelial protective factor. However, the role of 5-MTP in HH-induced ALI remains unclear.

Methods and results

Forty healthy male human participants were enrolled in Chongqing (200 m) to travel to Golmud (4260 m). We found the decreased plasma 5-MTP level was correlated with HH-induced blood oxygen desaturation and acute mountain sickness. ELISA showed 5-MTP levels decreased in the plasma and lungs of ALI mice (male 6-8 weeks C57BL/6J), and also in the supernatant of mouse pulmonary microvascular endothelial cells (PMVECs) after hypoxia. Immunoblotting showed the synthetase Asmt was downregulated in mice lungs an

SUBMITTER: Lai X 

PROVIDER: S-EPMC12681534 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature