Preclinical magnetic resonance imaging of proinflammatory epicardial adipose tissue: accelerated methods for simultaneous fatty acid composition and relaxation parameter mapping with relationships to tissue biomarkers.

ABSTRACT:

Background

Epicardial adipose tissue (EAT) plays a central role in metabolic heart disease through local inflammatory signaling. In obesity, EAT undergoes pathological remodeling marked by increased adipocyte size, saturated fatty acids (SFAs), macrophage infiltration, and inflammatory cytokine secretion. Proton density fat fraction (PDFF), relaxation times, and the fatty acid composition (FAC) (the amount of SFAs, monounsaturated fatty acids [MUFAs], and polyunsaturated fatty acids [PUFAs]) are promising metrics of EAT quality, yet their role as biomarkers of proinflammatory EAT has not been established. This study presents an accelerated cardiovascular magnetic resonance (CMR) method for simultaneous EAT FAC and relaxation time mapping and evaluates their relationships with histo

SUBMITTER: Bresticker JE 

PROVIDER: S-EPMC12681544 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature