Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure.

ABSTRACT: Heart failure (HF) is a common cardiovascular syndrome that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology remains poorly elucidated, primarily due to its inherent polygenic nature. Furthermore, these genetic insights have not been fully leveraged to develop effective primary treatment strategies for HF. In this study, we conducted a large-scale integrated multi-trait analysis using European ancestry genome-wide association study summary statistics of coronary artery disease and HF, involving nearly 2 million samples to identify risk loci associated with HF. Seventy-two loci were identified for HF using MTAG, of which 58 were supported in the replication phase. Transcriptome association analysis revealed 2

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12681555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature