A cone-beam computed tomography based workflow for online adaptive ultra-hypofractionated radiotherapy of prostate cancer.

ABSTRACT:

Background and purpose

Cone beam computed tomography (CBCT)-based approaches for online adaptive radiation therapy (oART) have recently become clinically available for ultra-hypofractionated prostate stereotactic body radiation therapy (SBRT). This work assessed the changes of relevant dose-volume-histogram (DVH) parameters and their robustness against morphologic variations during adaptation.

Materials and methods

Sixteen prostate cancer patients were treated with oART in an SBRT regimen (40 Gy in 5 treatment sessions (Tx) to the clinical target volume (CTV), PACE-B constraints). Two CBCTs were acquired daily: CBCT1 for adaptive planning and CBCT2 after adaptation for position verification. Adapted plans optimized on CBCT1 (ART_CBCT1) were recalculated on CBCT2 (A

SUBMITTER: Eckl M 

PROVIDER: S-EPMC12681559 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature