Age-structured vaccination strategies in mathematical modeling of malaria transmission.

ABSTRACT: Malaria is a global infectious disease, causing hundreds of thousands of deaths annually. This study presents an age-structured mathematical model for malaria vaccination that captures human and mosquito host interactions. Fundamental mathematical properties were established, and the stability of equilibria was analyzed in relation to the effective reproduction number (Re) . The system admits two equilibrium points: a malaria-free equilibrium and a malaria-endemic equilibrium. Analytical results showed that the malaria-free equilibrium is locally and globally asymptotically stable when Re<1 . Conversely, the malaria-endemic equilibrium is globally asymptotically stable when Re>1 . A sensitivity analysis of Re was performed to identify parameters influencing malaria transmission dynamics fo

SUBMITTER: Haringo AT 

PROVIDER: S-EPMC12681569 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature