NAB-paclitaxel and cisplatin versus gemcitabine and cisplatin as induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis.

ABSTRACT:

Background

The optimal induction chemotherapy (IC) regimen for locally advanced nasopharyngeal carcinoma (LA-NPC) remains uncertain.

Objectives

The study aims to compare the efficacy and safety of nanoparticle albumin-bound paclitaxel plus cisplatin (NAB-TP) versus gemcitabine plus cisplatin (GP) as IC in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Design

A retrospective analysis.

Methods

This study was conducted in LA-NPC patients treated at Sun Yat-sen University Cancer Center between 2012 and 2024. All patients received IC with either the GP or NAB-TP regimen followed by concurrent chemoradiotherapy (CCRT). Propensity score matching (PSM) was used to balance baseline characteristics between the GP and NAB-TP groups.

Results

In total, 90

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12681571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature