Characterizing Guillain-Barre Risk Factors Among Traditional Medicare Beneficiaries.

ABSTRACT: Guillain-Barré Syndrome (GBS) is a rare and potentially life-threatening autoimmune disorder affecting the peripheral nerves. We sought to identify demographic and clinical characteristics associated with GBS onset. In this retrospective case-control study, we used national 2005 to 2020 fee-for-service Medicare claims data to identify beneficiaries with incident GBS using a chart-validated algorithm (N = 16 280), matched 1:1 with non-GBS controls (N = 16 280) by age, sex, race/ethnicity, number of preventive care visits, and year of diagnosis. We then used 2 separate modified Poisson regressions to model GBS onset as a function of preceding (≤42 days) and preexisting (>42 days) clinical conditions, while further adjusting for age, sex, race/ethnicity, socioeconomic status, disability statu

SUBMITTER: Wright B 

PROVIDER: S-EPMC12681590 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature