Metabolic syndrome, accumulation of its components and risk of knee and hip replacement for osteoarthritis in community-dwelling older adults.

ABSTRACT:

Objective

To examined whether metabolic syndrome (MetS) and accumulation of its components were associated with incidence of knee and hip replacement for osteoarthritis in community-dwelling older individuals.

Design

This study examined 9179 women and 7524 men from the ASPREE trial. MetS was defined if at least three of the five criteria were present: central obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, hypertension, and dysglycemia. Knee and hip replacement for osteoarthritis were defined by hospitalisations during the ASPREE trial for knee and hip surgical procedures with the indication recorded as osteoarthritis.

Results

Over a mean follow-up of 4.0 (standard deviation 1.4) years, 547 women and 346 men had knee replacements and 404

SUBMITTER: Zeng M 

PROVIDER: S-EPMC12681691 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature