Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI.

ABSTRACT:

Background

Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention.

Methods

Participants aged 45-79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patient-reported outcomes. A Multi-state Markov (MSM) model evaluated state transitions and risk factors.

Results

The study comprised 2043 individuals (55.0 ​% female, 85.9 ​% White) with a total of 13,997 records of KOA state assessment. Of the individuals currently class

SUBMITTER: Nuer A 

PROVIDER: S-EPMC12681718 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature