An integrative approach to detecting potential blood-based biomarkers of cognitive frailty.

ABSTRACT:

Objective

Cognitive frailty, defined by the coexistence of cognitive decline and physical frailty, has been clinically defined, but its biological clues are still vague. This underscores the need for promising blood-based molecular biomarkers.

Design

Cross-sectional observational study.

Settings and participants

Frailty was diagnosed using the Japanese version of the Cardiovascular Health Study (J-CHS), and mild cognitive impairment was assessed with the Japanese version of the Montreal Cognitive Assessment (MoCA-J) and Mini-Mental State Examination-Japanese (MMSE-J). Participants with MMSE-J ≥24, MoCA-J score ≤25, and J-CHS score ≥1 were classified as having cognitive frailty. This study included 87 older adults aged ≥65 years, comprising 44 robust and 43 with cognit

SUBMITTER: Furutani M 

PROVIDER: S-EPMC12681723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature