Dual-wavelength UV photofunctionalization of 3D-printed Ti6Al4V porous bone implant enhances osseointegration via adhesion-cytoskeleton-nuclear mechanotransduction.

ABSTRACT: Orthopedic implants can be modified with ultraviolet (UV) photofunctionalization to improve osseointegration via force-sensing mechanotransduction in the microenvironment. Meanwhile, few researches have elucidated how UV wavelengths affect the photon-functionalized efficiency to promote synergistic osseointegration. Therefore, three-dimensional (3D)-printed porous Ti6Al4V implants were photofunctionalized with UVC (270 nm; G270), UVA (365 nm; G365), or UV-AC (270 + 365 nm; GU) to investigate the influence of different UV wavelengths on synergistic osseointegration via mechanotransduction. The alkaline phosphatase activity, hydrophilicity, and cytocompatibility of the porous Ti6Al4V implants were considerably higher following UV-AC treatment than following UVA or UVC treatment. Increased bo

SUBMITTER: Yin C 

PROVIDER: S-EPMC12681753 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature