Bariatric Surgery Alters Oral Microbiome: Evidence From Obese Patients and a Mouse Model.

ABSTRACT:

Background

Bariatric surgery (BaS) is a safe and effective treatment for severe obesity, yet recent studies suggested that it may impact the gut and oral microbiomes. Oral dysbiosis is associated with an increased risk of oral diseases, including periodontitis and dental caries. However, the effects of BaS on oral health and microbiome changes are poorly understood.

Objectives

To examine the impact of obesity and BaS on oral health and microbiota in obese patients and an induced experimental periodontitis (EP) obese mouse model.

Methods

The oral health of pre-BaS, post-BaS (6 months post-surgery), and control volunteers was assessed by scoring gingivitis, caries, and periodontitis. The oral microbiome was analyzed using 16S rRNA Next-Generation sequencing (NGS). Syste

SUBMITTER: Shahin A 

PROVIDER: S-EPMC12681780 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature