The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC.

ABSTRACT: N6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotes, is critical for posttranscriptional regulation. The m6A reader YTH domain-containing family protein 1 (YTHDF1) acts as an oncogene in multiple malignancies, yet its specific roles and regulatory mechanisms in nasopharyngeal carcinoma (NPC) have not been fully elucidated. This study elucidates a novel epitranscriptional axis whereby YTHDF1 drives NPC progression via posttranscriptional regulation of c-MYC. Clinical analyses reveal YTHDF1 is overexpressed in a subset of NPC specimens, with high expression correlating with advanced stage and poor patient outcomes, supporting its potential as a prognostic biomarker. Functional assays demonstrate that YTHDF1 enhances NPC proliferation, migration, and invasion in vitro

SUBMITTER: Han P 

PROVIDER: S-EPMC12681820 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature