PIK3C2B drives lung cancer progression through coordinating metabolic reprogramming and EMT-mediated metastasis.

ABSTRACT: Lung cancer is the leading cause of cancer-related mortality worldwide, is driven by metastatic dissemination and metabolic adaptation. However, the underlying mechanisms remain poorly understood. This study identifies PIK3C2B, an understudied isoform of PI3K, as a key regulator of these processes. Integrative transcriptomics analysis of eight GEO datasets revealed 336 consistently dysregulated genes, with PIK3C2B emerging as a candidate associated with metastasis. Elevated expression of PIK3C2B was correlated with reduced overall survival (log-rank p < 0.05) and shorter disease-free survival (p < 0.05) in lung adenocarcinoma patients. Immunohistochemistry confirmed PIK3C2B overexpression in patient tumors. Functional validation showed that silencing PIK3C2B impaired proliferation and migr

SUBMITTER: Chou X 

PROVIDER: S-EPMC12681860 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature