Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis.

ABSTRACT: Objectives: Dysfunctional autophagy during aging is a universal inducer of a variety of degenerative diseases. Here, we aim to identify important non-coding RNAs that are crucial for the regulation of osteoarthritis (OA) and age-associated diseases. In addition, we also aim to explore the underlying molecular mechanisms and potential therapeutic strategies. Methods: RNA sequencing based screening was used to identify potential inflammation and autophagy associated key non-coding RNAs. After the identification of targeting molecular circPLXNC1, we examined its expression profile during OA development and in other aging organs and tissues. In addition, knock down of circPLXNC1 both in vitro and in vivo was used for the functional assays. The downstream targets, mi

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12681868 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature