Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination.

ABSTRACT: Endothelial injury is an early event in chronic kidney disease (CKD) leading to renal hemodynamic disorders and even glomerulosclerosis. During this process, both oxidative stress and inflammation originating from injured endothelial cells can initiate pathogenic cell-to-cell interactions via a paracrine mechanism. Accumulating evidence underscores the pivotal role of mitochondrial dysfunction as a crucial mechanism underlying endothelial dysfunction. Lon protease 1 (LONP1) is a mitochondrial protease that plays a key role in maintaining mitochondrial homeostasis; however, its role in endothelial dysfunction-related renal disease is unknown. In CKD patients and mice subjected to 5/6 nephrectomy (5/6Nx), we observed decreased LONP1 expression in glomerular endothelial cells. Interestingly,

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12681905 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature