Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms: A Children's Oncology Group Study.

ABSTRACT:

Background

Early echocardiographic indicators of cardiac remodeling may enhance cardiomyopathy risk prediction in childhood cancer survivors (CCS).

Objectives

The objective of the study was to assess whether influential echocardiographic measures can be combined to develop a robust cardiomyopathy risk prediction model in CCS.

Methods

Multicenter retrospective study of ≥1-year CCS with digitally archived surveillance echocardiograms, enrolled cardiomyopathy cases (left ventricular [LV] fractional shortening ≤28% or LV ejection fraction ≤50% on ≥2 occasions) and noncases (≥5-year CCS who maintained fractional shortening ≥ 30% and ejection fraction ≥55% without initiation of cardiac medications). Echocardiograms were centrally quantitated in a blinded fashion. Least abso

SUBMITTER: Leger KJ 

PROVIDER: S-EPMC12681922 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature