Meox1 Promotes Cardiac Fibrosis and Pathological Remodeling following Myocardial Infarction through Cthrc1/p-Smad2/3 Signaling.

ABSTRACT: Aims: Myocardial infarction (MI) induces pathological cardiac fibrosis and ventricular remodeling, which leads to cardiac dysfunction and heart failure. Mesenchyme homeobox 1 (Meox1) was shown to be an essential transcriptional switch in fibroblasts activation; however, whether Meox1 is involved in the fibrosis process following MI remains unknown. We aimed to explore the role of Meox1 in cardiac fibrosis and remodeling post-MI and its underlying mechanisms. Methods and results: Herein, we identified that Meox1 was highly expressed in activated fibroblasts (myofibroblasts, Myofbs), in response to MI in mice or transforming growth factor beta 1 (TGF-β1) stimulation in primary cardiac fibroblasts (CFs). Knockdown of Meox1 in Myofbs remarkably attenuated cardiac fibrosis and adv

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12681941 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature