Childhood outcomes of fetal genomic copy-number variants: The prenatal microarray cohort study.

ABSTRACT:

Purpose

The long-term developmental outcomes of children with a prenatal diagnosis of a copy-number variant of uncertain significance (VUS) remain unclear. This study compared the developmental, social-emotional, and health outcomes of children with and without a prenatal VUS, assessed maternal perceptions of their child's health and development, and examined the reclassification rate of VUS after more than 2 years.

Methods

Women who underwent prenatal chromosomal microarray testing in Victoria, Australia (2013-2019), were recruited retrospectively (2021-2023). Children with a VUS (cases) were compared with controls without a VUS. We assessed a range of cognitive, developmental, and health outcomes in the children, who were on average 6 years old. Statistical analyses compar

SUBMITTER: McCoy J 

PROVIDER: S-EPMC12681968 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature