Development and validation of an individualized online calculator for early mortality risk after hepatectomy among patients with HCC.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally. Despite improved surgical techniques, early post-hepatectomy mortality remains a critical concern. Current staging systems and liver function classifications fail to estimate early mortality risk to guide surgical decision-making. We aimed to develop and validate an individualized online calculator to predict early post-hepatectomy mortality for HCC.

Methods

Patients undergoing curative-intent hepatectomy for HCC from 2011 to 2021 at 11 Chinese centers were included. The training cohort comprised nine centers, while the external validation cohort included two centers. Multivariable logistic regression identified predictors of postoperative 90-day mortality, which were incorporated

SUBMITTER: Wang SY 

PROVIDER: S-EPMC12681976 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature